Effects of pore size, implantation time, and nano-surface properties on rat skin ingrowth into percutaneous porous titanium implants.

摘要: The main problem of percutaneous osseointegrated implants is poor skin-implant integration, which may cause infection. This study investigated the effects pore size (Small, 40-100 μm and Large, 100-160 μm), nanotubular surface treatment (Nano), duration implantation (3 6 weeks) on skin ingrowth into porous titanium. Each implant type was percutaneously inserted in back 35 rats randomly assigned to seven groups. Implant extrusion rate measured weekly determined histologically after harvesting implants. It found that all three types demonstrated tissue over 30% (at week 3) 50% weeks 4-6) total area under skin; longer resulted greater (p < 0.05). Only one case infection observed (infection 2.9%). Small Nano groups showed same lower than Large group (0.06 ± 0.01 vs. 0.16 0.02 cm/week; p Ingrowth comparable Small, However, qualitatively, greatest cellular inhabitation within first 3 weeks. We concluded titanium allow for integration with potential a safe seal.