Mechanisms of Intralysosomal Degradation with Special Reference to Autophagocytosis and Heterophagocytosis of Cell Organelles

摘要: Publisher Summary This chapter describes the mechanisms of intralysosomal degradation with a special reference to autophagocytosis and heterophagocytosis cell organelles. Autophagy is process sequestration intracellular components their subsequent by lysosomes. The fundamental importance in function because under steady-state conditions subcellular are broken down resynthesized many times during life span cells. contributes turnover constituents physiological conditions. induced numerous treatments, conditions, or agents that cause dysfunction. Biological from extracellular space can also enter lysosomal compartment become degraded through heterophagy. discusses an experimental model which organelles introduced into apparatus Kupffer cells means study heterophagic has advantages over autophagy each membrane constituent organelle be separately studied. heterophagy useful evaluate capacity lysosomes degrade various vivo .