Safety of intravenous methamphetamine administration during treatment with bupropion

摘要: Methamphetamine dependence is a growing problem for which no medication treatments have proven effective. We evaluated bupropion, an antidepressant with beneficial effects the treatment of nicotine dependence, in patients methamphetamine to assess safety and tolerability administration during bupropion treatment. Twenty-six participants entered study 20 completed protocol. Participants received intravenous (0, 15, 30 mg) before after randomization twice-daily (150 mg SR) or matched placebo. Dependent measures included cardiovascular methamphetamine, amphetamine pharmacokinetics, peak trough plasma concentrations its metabolites. Bupropion was well tolerated, bupropion- placebo-treated groups reporting similar rates adverse events. associated expected stimulant effects, these were not accentuated by Instead, there trend reduce methamphetamine-associated increases blood pressure statistically significant reduction heart rate. Pharmacokinetic analysis revealed that reduced clearance also appearance plasma. did alter tolerated There evidence additive when drugs coadministered. This provides initial prescribing abuse dependence. The impact who larger doses remains undetermined.