Volumes of brain structures in captive wild-type and laboratory rats: 7T magnetic resonance in vivo automatic atlas-based study.

摘要: Selective breeding of laboratory rats resulted in changes their behavior. Concomitantly, the albino strains developed vision related pathologies. These alterations certainly occurred on background modifications brain morphology. The aim study was to assess and compare volumes major structures brains wild-captive, pigmented rats. High resolution T2-weighted images adult male Warsaw Wild Captive Pisula-Stryjek (WWCPS, a model wild type), (Brown Norway strain, BN) (Wistar WI) were obtained with 7T small animal-dedicated magnetic resonance tomograph. Volume quantification whole 50 within each performed digital Schwarz rat atlas custom-made MATLAB/SPM8 scripts. Brain scaled body mass, whereas normalized individual volumes. Normalized volume similar WWCPS BN, but lower WI. neocortex smaller both than visual cortex WI BN. Relative phylogenetically older structures, such as hippocampus, amygdala, nucleus accumbens olfactory nuclei, also displayed certain strain-related differences. present data shows that selective markedly affected morphology, being most significantly altered. In particular, display reduced cortex, possibly retinal degeneration development blindness.