Biomimetic Sensors for the Senses: Towards Better Understanding of Taste and Odor Sensation.

作者: Chunsheng Wu , Ya-Wen Du , Liquan Huang , Yaron Ben-Shoshan Galeczki , Ayana Dagan-Wiener

DOI: 10.3390/S17122881

关键词:

摘要: Taste and smell are very important chemical senses that provide indispensable information on food quality, potential mates danger. In recent decades, much progress has been achieved regarding the underlying molecular cellular mechanisms of taste odor senses. Recently, biosensors have developed for detecting odorants tastants as well studying ligand-receptor interactions. This review summarizes currently available biosensing approaches, which can be classified into two main categories: in vitro vivo approaches. The former is based utilizing biological components such olfactory tissues, cells receptors, sensitive elements. latter dependent signals recorded from animals' signaling pathways using implanted microelectrodes living animals. Advantages disadvantages these differences terms sensing principles applications highlighted. current challenges, future trends prospects research biomimetic sensors discussed.

参考文章(118)
P Fromherz, A Offenhausser, T Vetter, J Weis, A neuron-silicon junction: a Retzius cell of the leech on an insulated-gate field-effect transistor. Science. ,vol. 252, pp. 1290- 1293 ,(1991) , 10.1126/SCIENCE.1925540
Diming Zhang, Fenni Zhang, Qian Zhang, Yanli Lu, Qingjun Liu, Ping Wang, None, Umami evaluation in taste epithelium on microelectrode array by extracellular electrophysiological recording Biochemical and Biophysical Research Communications. ,vol. 438, pp. 334- 339 ,(2013) , 10.1016/J.BBRC.2013.07.072
Laurence Dryer, Anna Berghard, Odorant receptors: a plethora of G-protein-coupled receptors Trends in Pharmacological Sciences. ,vol. 20, pp. 413- 417 ,(1999) , 10.1016/S0165-6147(99)01381-4
Liping Du, Chunsheng Wu, Qingjun Liu, Liquan Huang, Ping Wang, Recent advances in olfactory receptor-basedbiosensors Biosensors and Bioelectronics. ,vol. 42, pp. 570- 580 ,(2013) , 10.1016/J.BIOS.2012.09.001
Einav Malach, Merav E. Shaul, Irena Peri, Liquan Huang, Andrew I. Spielman, Rony Seger, Michael Naim, Membrane-permeable tastants amplify β2-adrenergic receptor signaling and delay receptor desensitization via intracellular inhibition of GRK2's kinase activity. Biochimica et Biophysica Acta. ,vol. 1850, pp. 1375- 1388 ,(2015) , 10.1016/J.BBAGEN.2015.03.015
Umberto Pace, Emanuel Hanski, Yoram Salomon, Doron Lancet, Odorant-sensitive adenylate cyclase may mediate olfactory reception Nature. ,vol. 316, pp. 255- 258 ,(1985) , 10.1038/316255A0
Liping Du, Ling Zou, Luhang Zhao, Liquan Huang, Ping Wang, Chunsheng Wu, Label-free functional assays of chemical receptors using a bioengineered cell-based biosensor with localized extracellular acidification measurement Biosensors and Bioelectronics. ,vol. 54, pp. 623- 627 ,(2014) , 10.1016/J.BIOS.2013.11.049
Harumi Saito, Momoka Kubota, Richard W. Roberts, Qiuyi Chi, Hiroaki Matsunami, RTP Family Members Induce Functional Expression of Mammalian Odorant Receptors Cell. ,vol. 119, pp. 679- 691 ,(2004) , 10.1016/J.CELL.2004.11.021
Jong Hwan Sung, Hwi Jin Ko, Tai Hyun Park, Piezoelectric biosensor using olfactory receptor protein expressed in Escherichia coli. Biosensors and Bioelectronics. ,vol. 21, pp. 1981- 1986 ,(2006) , 10.1016/J.BIOS.2005.10.002
Qingjun Liu, Ning Hu, Weiwei Ye, Hua Cai, Fenni Zhang, Ping Wang, Extracellular recording of spatiotemporal patterning in response to odors in the olfactory epithelium by microelectrode arrays Biosensors and Bioelectronics. ,vol. 27, pp. 12- 17 ,(2011) , 10.1016/J.BIOS.2011.03.010