Direct Solvent-Free Regioselective Construction of Pyrrolo[1,2-a][1,10]phenanthrolines Based on Isocyanide-Based Multicomponent Reactions
作者： Ming Li , Xiu-Liang Lv , Li-Rong Wen , Zhi-Qiang Hu
DOI: 10.1021/OL400191B
关键词:
摘要: A novel efficient one-pot four-component regioselective synthesis of pyrrolo[1,2-a][1,10]phenanthrolines in excellent yields has been developed by 1,3-dipolar cycloaddition aldehydes, malononitrile, and isocyanides with 1,10-phenanthroline under solvent-free conditions within 3 min without using any catalyst or activation. The products were preliminarily investigated as chromogenic fluorescent sensors for Cu2+ ions.
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