Hepatic neutrophil migration, kinetics and long-term outcome in severe alcoholic hepatitis

摘要: Alcohol-related liver disease (ARLD) refers to the spectrum of hepatic pathology arising from excessive alcohol consumption. In contrast most continental Europe, where incidence is falling, ARLD a growing clinical problem in UK and currently accounts for ten percent all deaths occurring between 40 - 49 years age. Severe alcoholic hepatitis (AH) arguably florid manifestation ARLD, presenting with jaundice features decompensation, often those without an existing diagnosis disease. Despite abstinence short-term mortality approaches 40%, which may be improved by early timely medical therapy. Among current controversies management severe AH are necessity biopsy confirm diagnosis, hence there recognised need non-invasive diagnostic aids. Corticosteroids have remained mainstay therapy over 30 years, although significant minority fail respond particularly susceptible infections as consequence treatment. A means prospectively non-invasively identifying these individuals would advancement.