Early urine proteome changes in an implanted bone cancer rat model.
作者： Ting Wang , Lujun Li , Weiwei Qin , Youhe Gao
DOI: 10.1016/J.BONR.2019.100238
关键词:
摘要: Abstract In this study, Walker 256 cells were implanted into rat tibiae. Urine samples then collected on days 3, 5, 7, and 13 analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). With label-free quantification, 25 proteins found to change significantly in the urine of tumor group rats compared with control rats; was even case when there no significant lesions identified Computed Tomography (CT) examination. Among these differentially proteins, 7 reported be associated bone metastasis. GO analysis shows that differential day 3 involved several responses, including acute phase response, adaptive immune response innate response. The mineral absorption pathway. vitamin D binding calcium ion binding. These processes may Our results demonstrate could sensitively reflect changes early stage cancer; provides valuable clues for future studies biomarkers
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