Bleomycin gene cluster components and their uses
作者： Ben Shen , Liangcheng Du , Mei Chen , Cesar Sanchez , Daniel J. Edwards
DOI:
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摘要: This invention provides detailed sequence analysis and characterization of the gene cluster responsible for synthesis bleomycin in Streptomyces verticillus. The first hybrid polyketide synthase/nonribosomal peptide synthetase pathway elucidation various modules enzymatic domains characterizing convenient synthetic routes bleomycins, analogs, other polyketides.
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