5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases

摘要: The present invention relates to C ompounds having the structure of Formula I: wherein n is an integer from 1 5; R1 optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alkenyloxy or alkynyloxy; R2 allcynyl, NR4R5, -NHC(=Y)R4, - NHC(=Y)NR5Rχ, -NHC(=O)OR4, -NHSO2R4, C(=Y)NR4R5, C(=O)OR6 [wherein Y oxygen sulphur], OR5, -O(C=O)NR4R5, O-acyl, S(O)mR4, -SO2N(R4)2, cyano, amidino guanidino R4 heteroarylalkyl, heterocyclylalkyl cycloalkylalkyl and m 0-2; R5 hydrogen R4; Rx -SO2N(R4)2 R6 hydrogen, cycloalkylalkyl]; R3 fluorine, aralkyl; A OH, OR4, -OC(=O)NR4R5, NH2, -NHC(=Y)NR5Rx, NHC(=O)OR4, processes for synthesis same. This also pharmacological compositions containing compounds invention, methods treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic psoriasis, pulmonary fibrosis inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads restenosis ischemic heart failure, stroke, renal diseases, tumor metastasis, other inflammatory disorders characterized by over-expression over-activation matrix metalloproteinase, using compounds.