Biologically active Phytophthora mating hormone prepared by catalytic asymmetric total synthesis

摘要: A Phytophthora mating hormone with an array of 1,5-stereogenic centers has been synthesized by using our recently developed methodology catalytic enantioselective conjugate addition Grignard reagents. We applied this in a diastereo- and iterative route obtained two the 16 possible stereoisomers α1. These synthetic induced formation sexual spores (oospores) A2 type strains three heterothallic species, P. infestans, capsici, nicotianae but not A1 strains. The response was concentration-dependent, oospores were viable. results demonstrate that biological activity resembles natural Mating hormones are essential components life cycle variety organisms. For plant pathogens like Phytophthora, reproduction is important as source genetic variation. Moreover, thick-walled most durable propagules can survive harsh environmental conditions. Sexual thus greatly affect disease epidemics. availability compounds mimicking will be instrumental for further unravelling group pathogens.