Molecular weight-modulated electrospun poly(ε-caprolactone) membranes for postoperative adhesion prevention

摘要: Electrospun biodegradable polymer membranes can effectively serve as barriers to prevent postoperative intestinal adhesion. Previous studies have largely focused on utilizing different electrospun variables regulate membrane properties, but paid very limited attention the straightforward influences of raw material characteristics. In present work, physical and physiological properties poly(e-caprolactone) (PCL) with varying viscosity-average molecular weights (Mη = 40 000, 80 000 120 000 g mol−1) were explored for first time. Interestingly, typical films, such morphological structure, mechanical degradation kinetics anti-adhesion effect, revealed be substantially dependent weight. clear contrast, PCL sample weight mol−1 exhibited best performance, including a regular fibrous morphology, superior tensile strength Young's modulus 1.13 8.41 MPa, respectively, which was presumably ascribed means chain entanglements interactions. Most importantly, no cytotoxicity traced in from cell culture test; moreover, significant reduction adhesion observed. Because above mentioned excellent merits, regarded candidates applications.