The CXCR4-CXCL12 axis in Ewing sarcoma: promotion of tumor growth rather than metastatic disease
作者： Dagmar Berghuis , Marco W Schilham , Susy J Santos , Suvi Savola , Helen J Knowles
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摘要: Background Chemokine receptor CXCR4, together with its ligand CXCL12, plays critical roles in cancer progression, including growth, metastasis and angiogenesis. Ewing sarcoma is a poor prognosis despite current therapies, particularly for patients advanced-stage disease. Lungs bone (marrow), organs of predilection (primary/metastatic) sarcoma, represent predominant CXCL12 sources.
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