White Adipose Tissue and Circadian Rhythm Dysfunctions in Obesity: Pathogenesis and Available Therapies

摘要: A combined neuroendocrine, metabolic, and chronobiological view can help to better understand the multiple complex mechanisms involved in obesity development maintenance, as well provide new effective approaches for its control treatment. Indeed, we have currently updated data on whole adipogenic process white adipose tissue (WAT) mass expansion, namely due a mechanism whereby WAT cells become hypertrophic, thus inducing serious local inflammatory condition that turn, will impair not only cross-talk between hypothalamus WAT, but also favoring of deep widespread neuroendocrine-metabolic dysfunction. Moreover, revisited circadian clock genes dysfunctional expansion may lead development, including early metabolic dysfunctions, enhanced oxidative stress distorted energy homeostasis. The epigenetic changes driving disease been included this review. Finally, underlined relevance homeostasis regulation by central peripheral organ clocks, sleep disturbances, nutrients, feeding time, key factors both, classical chronotherapeutic prevention