Corroborative models of the cobalt(II) inhibited Fe/Mn superoxide dismutases.

摘要: Attempting to model superoxide dismutase (SOD) enzymes, we designed two new N3O-donor ligands provide the same set of donor atoms observed in active site these enzymes:  KiPr2TCMA (potassium 1,4-diisopropyl-1,4,7-triazacyclononane-N-acetate) and KBPZG N,N-bis(3,5-dimethylpyrazolylmethyl) glycinate). Five CoII complexes (1−5) were obtained characterized by X-ray crystallography, mass spectrometry, electrochemistry, magnetochemistry, UV−vis, electron paramagnetic resonance (EPR) spectroscopies. The crystal structures 1 3−5 revealed five-coordinate complexes, whereas complex 2 is six-coordinate. EPR data 3 4 agree with those CoII-substituted SOD, which strongly support proposition that enzyme structurally resembles models. redox behavior 1−5 clearly demonstrates stabilization state ligand field provided ligands. irreversibility displayed all compl...