Rheumatoid Arthritis
作者： Jisna R Paul , Deepali Sen , Prabha Ranganathan
DOI: 10.1016/B978-0-12-386882-4.00029-3
关键词:
摘要: Rheumatoid arthritis (RA) is an inflammatory disease that can cause severe joint destruction and disability, with subsequent high morbidity mortality. Disease-modifying antirheumatic drugs (DMARDs) are the cornerstones of RA treatment. They not only relieve pain, swelling, stiffness but also slow radiographic progression disease. Over last 10–15 years, a new class disease-modifying medications, biologic agents, has been added to armementarium DMARDs, they highly effective. However, there remains considerable heterogeneity in patients’ response these agents. Pharmacogenetics may offer reliable means predicting individual patient’s given DMARD prior initiation therapy. In this chapter, we review current literature on pharmacogenetics traditional DMARDS RA. holds promise individualizing drug
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