Influence of the Previous Deep Inspiration on the Spirometric Measurement of Provoked Bronchoconstriction in Asthma1,2

摘要: The measurement of the forced expiratory volume in one second (FEV,) after a maximal inspiration is often used to assess effect inhaled bronchoconstrictor agents. In persons with asthma, deep transiently alters bronchial tone variable way. This may result decrease FEV1 despite similar degree pharmacologically induced bronchospasm. 71 patients asthma we comparable increase (approximating 200 %) airway resistance (Raw) aerosolized carbachol. We then measured change Raw by inspiration; when had returned value observed before inspiration, was measured. A significant correlation (r = 0.74; p < 0.001) found between transient changes (ranging individually from 33 % 70% decrease) and FEV, (from 0 70 %). greatest whom increased least those in...