Renal complications in HIV disease: between present and future.

作者: Antonio Di Biagio , Vincenzo Montinaro , Pasquale Narciso , Paolo Bonfanti , Stefano Rusconi

DOI:

关键词:

摘要: The recent introduction of new antiretroviral drugs, characterized by high efficiency and improved safety profiles, has not reduced the incidence long-term adverse effects, in some cases manifested as selective organ damage. presence damage patients receiving treatment is only expression toxicity, but also a complex interaction between individual risk factors, HIV-correlated drug toxicity. Kidney belongs to these events. Renal function abnormalities are present large percentage with HIV infection. Moreover, HIV-associated renal disease seems be associated progression AIDS death. In this review we address various aspects epidemiology damage, convergent effect drugs onset kidney injury, interplay other systems, early clinical management, monitoring function, proposal approach daily practice. Finally, discuss future perspectives evaluate patient’s perspective.

参考文章(130)
P L Kimmel, W O Umana, J P Bosch, Abnormal urinary protein excretion in HIV-infected patients Clinical Nephrology. ,vol. 39, pp. 17- 21 ,(1993)
Lynda A Szczech, Renal dysfunction and tenofovir toxicity in HIV-infected patients. Topics in HIV medicine : a publication of the International AIDS Society, USA. ,vol. 16, pp. 122- 126 ,(2008)
Antonio Carlos Seguro, Magali de Araujo, Trimethoprim-sulfamethoxazole (TMP/SMX) potentiates indinavir nephrotoxicity. Antiviral Therapy. ,vol. 7, pp. 181- 184 ,(2002)
Barry M. Brenner, Brenner & Rector's the Kidney ,(1996)
F Tordato, A Cozzi Lepri, P Cicconi, A De Luca, A Antinori, V Colangeli, A Castagna, P Nasta, N Ladisa, A Giacometti, A D'Arminio Monforte, A Gori, , Evaluation of glomerular filtration rate in HIV-1-infected patients before and after combined antiretroviral therapy exposure. Hiv Medicine. ,vol. 12, pp. 4- 13 ,(2011) , 10.1111/J.1468-1293.2010.00855.X
Christoph A Fux, Mathew Simcock, Marcel Wolbers, Heiner C Bucher, Bernard Hirschel, Milos Opravil, Pietro Vernazza, Matthias Cavassini, Enos Bernasconi, Luigia Elzi, Hansjakob Furrer, Swiss HIV Cohort Study, Tenofovir use is associated with a reduction in calculated glomerular filtration rates in the Swiss HIV Cohort Study. Antiviral Therapy. ,vol. 12, pp. 1165- 1173 ,(2007)
Gregory M Lucas, Shruti H Mehta, Mohamed G Atta, Gregory D Kirk, Noya Galai, David Vlahov, Richard D Moore, End-stage renal disease and chronic kidney disease in a cohort of African-American HIV-infected and at-risk HIV-seronegative participants followed between 1988 and 2004. AIDS. ,vol. 21, pp. 2435- 2443 ,(2007) , 10.1097/QAD.0B013E32827038AD