Injectable Colloidal Gold in a Sucrose Acetate Isobutyrate Gelating Matrix with Potential Use in Radiation Therapy
作者： Rasmus I. Jølck , Tina Binderup , Anders E. Hansen , Jonas B. Scherman , Per Munch af Rosenschold
关键词:
摘要: External beam radiation therapy relies on the ability to deliver high doses tumor cells with minimal exposure surrounding healthy tissue. Advanced irradiation techniques, including image-guided (IGRT), rely locate tumors optimize therapeutic benefit of these techniques. Today, radiopaque fiducial tissue markers are placed in or around tumors, for example, prostate cancer patients enhance precision daily and/or real-time IGRT. A liquid injectable marker (nanogel) is developed based PEGylated gold nanoparticles and sucrose acetate isobutyrate (SAIB) improved properties compared current solid markers. The nanogel investigated vitro subsequently evaluated vivo immunocompetent NMRI mice. shows CT-contrast excellent stability over a period 12 weeks. found be biocompatible well tolerated. No induction inflammatory cytokines INF-γ, IL-6, TNF-α observed throughout study period. seems safe ideally suited IGRT that may further effect radiation.
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