The recent report by Liu and Zhang Claiming “No support for the adaptive hypothesis of lagging-strand encoding in bacterial genomes” is factually incorrect

摘要: Abstract In their manuscript1 entitled “No support for the adaptive hypothesis of lagging-strand encoding in bacterial genomes”, Liu and Zhang attempt to refute findings our 2018 Nature Communications paper2. Here, we demonstrate that multiple key claims made by are factually incorrect, overall conclusions, including title paper, invalid. We show existing controls already preclude null proposed Zhang. also authors falsely claim did not publish data, when fact, these data were presented manuscript. Similarly, point out comparisons logical arguments never made. Furthermore, they reanalyzed fact not. Therefore, could not, definition, have identified errors data. Our reanalysis reveals main problem is simply do understand meaning term “inversion”. This caused them misjudge limitations both own inversion detection technique ours. find method cannot, specifically, identify inversions. Lastly, provide new empirical evidence demonstrating further works properly as described original conclude Zhang’s manuscript has no rational basis, meets criteria acceptance based on standards.