Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis.

作者: Jay D. Morton , Lichiro Shimomura

DOI: 10.1097/00041433-199904000-00008

关键词:

摘要: A family of transcription factors designated sterol regulatory element-binding proteins (SREBPs) mediates the previously described end-product feedback regulation cholesterol biosynthesis. In addition, SREBPs are emerging as important regulators fatty acid synthesis. The current review focuses on in-vivo in liver and coordinate SREBP-activated target genes.

参考文章(36)
G.M. Tomkins, I.L. Chaikoff, CHOLESTEROL SYNTHESIS BY LIVER I. INFLUENCE OF FASTING AND OF DIET Journal of Biological Chemistry. ,vol. 196, pp. 569- 573 ,(1952) , 10.1016/S0021-9258(19)52391-2
S.N. Gershoff, C.A. Elvehjem, Studies of the biological effects of methionine sulfoximine. Journal of Biological Chemistry. ,vol. 192, pp. 569- 574 ,(1951) , 10.1016/S0021-9258(19)77779-5
J B Kim, G D Spotts, Y D Halvorsen, H M Shih, T Ellenberger, H C Towle, B M Spiegelman, Dual DNA Binding Specificity of ADD1/SREBP1 Controlled by a Single Amino Acid in the Basic Helix-Loop-Helix Domain Molecular and Cellular Biology. ,vol. 15, pp. 2582- 2588 ,(1995) , 10.1128/MCB.15.5.2582
J D Horton, I Shimomura, M S Brown, R E Hammer, J L Goldstein, H Shimano, Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. Journal of Clinical Investigation. ,vol. 101, pp. 2331- 2339 ,(1998) , 10.1172/JCI2961
Eva J. Neer, Carl J. Schmidt, Raman Nambudripad, Temple F. Smith, The ancient regulatory-protein family of WD-repeat proteins Nature. ,vol. 371, pp. 297- 300 ,(1994) , 10.1038/371297A0
Juro Sakai, Robert B Rawson, Peter J Espenshade, Dong Cheng, Adam C Seegmiller, Joseph L Goldstein, Michael S Brown, Molecular Identification of the Sterol-Regulated Luminal Protease that Cleaves SREBPs and Controls Lipid Composition of Animal Cells Molecular Cell. ,vol. 2, pp. 505- 514 ,(1998) , 10.1016/S1097-2765(00)80150-1
Juro Sakai, Axel Nohturfft, Dong Cheng, Y. K. Ho, Michael S. Brown, Joseph L. Goldstein, Identification of Complexes between the COOH-terminal Domains of Sterol Regulatory Element-binding Proteins (SREBPs) and SREBP Cleavage-Activating Protein Journal of Biological Chemistry. ,vol. 272, pp. 20213- 20221 ,(1997) , 10.1074/JBC.272.32.20213
H Shimano, J D Horton, R E Hammer, I Shimomura, M S Brown, J L Goldstein, Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. Journal of Clinical Investigation. ,vol. 98, pp. 1575- 1584 ,(1996) , 10.1172/JCI118951
Marisa M. Magaña, Timothy F. Osborne, Two Tandem Binding Sites for Sterol Regulatory Element Binding Proteins Are Required for Sterol Regulation of Fatty-acid Synthase Promoter Journal of Biological Chemistry. ,vol. 271, pp. 32689- 32694 ,(1996) , 10.1074/JBC.271.51.32689
James M. Ntambi, The regulation of stearoyl-CoA desaturase (SCD). Progress in Lipid Research. ,vol. 34, pp. 139- 150 ,(1995) , 10.1016/0163-7827(94)00010-J