Quercetin Enhanced Paclitaxel Therapeutic Effects Towards PC-3 Prostate Cancer Through ER Stress Induction and ROS Production.
作者： Xiangyu Zhang , Jingwen Huang , Chao Yu , Longquan Xiang , Liang Li
DOI: 10.2147/OTT.S228453
关键词:
摘要: Introduction Prostate cancer is one of the most common cancers threatening public health worldwide. Although chemotherapy plays an important role in treating prostate cancer, it leads to many adverse effects and prone drug resistance. Quercetin, a natural product, used traditional Chinese medicine because its strong antitumor activity few side effects. Methods In this study, we combined quercetin paclitaxel kill cells vivo vitro, investigated relevant mechanism combination treatment. After were treated with or/and paclitaxel, cell growth inhibition, apoptosis, cycle, reactive oxygen species (ROS) generation, several endoplasmic reticulum (ER) stress signaling pathway related gene expressions evaluated. Results The treatment significantly inhibited proliferation, increased arrested cycle at G2/M phase, migration, dramatically induced ER occur, ROS generation. PC-3 cancer-bearing murine model, exerted beneficial therapeutic effects, cell-killing nearly no compared single group. Conclusion Combination possessed enhanced anti-cancer these results will provide basis for using paclitaxel.
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