Asymmetric solid-phase alkylation of ketones immobilized via SAMP hydrazone analogue linkers.
作者： Ryszard Lazny , Aneta Nodzewska , Beata Zabicka
DOI: 10.1021/CC8001298
关键词:
摘要: The preparation and application of new solid supports with chiral linkers, analogues SAMP hydrazine on solid-phase, are described. were used for immobilization ketones (diethylketone, cyclohexanone, 4-tert-butylcyclohexanone), diastereoselective alkylation formed ketone hydrazones. enantiomeric purities cleaved α-alkylated ranged from 10 to 73%. use lithium amides metalation hydrazones t-butylcyclohexanone increased the excess alkylated product by 25−47%.
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