Levels and profiles of PCDDs, PCDFs and cPCBs in Belgian breast milk. Estimation of infant intake.

作者: J.-F Focant , C Pirard , C Thielen , E De Pauw

DOI: 10.1016/S0045-6535(02)00140-6

关键词:

摘要: Congener-specific analyses of polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and non-ortho (coplanar) biphenyls (cPCBs) were performed on 20 non-pooled breast milk samples collected in or close to an industrial area Wallonia (Belgium). PCDD/F concentrations ranged between 16.0 52.1 pg TEQ/g fat, with a mean value 29.4 fat. If coplanar PCBs (77, 126, 169) are included TEQ calculations, levels 22.2 100.2 40.8 It appears that 2,3,7,8-TCDD, 1,2,3,7,8-PeCDD, 2,3,4,7,8-PeCDF PCB-126 account for more than 90% the TEQ. Estimated dietary intake is 76 TEQ/kg body weight (bw)/day. This almost times higher World Health Organization tolerable daily intake. A 103 bw/day represents PCDDs, PCDFs cPCBs (no mono-ortho included).

参考文章(29)
S Fierens, Jean-François Focant, JE Andre, Gauthier Eppe, Edwin De Pauw, None, Dioxin Body Burden of Populations Living in the Vicinity of Two Municipal Solid Waste Incinerators (MSWI) in Belgium Organohalogen compounds. ,vol. 52, ,(2001)
M.J. Gonz�lez, L. Ramos, L.M. Hern�ndez, Levels of coplanar PCBs in human breast milk at different times of lactation Bulletin of Environmental Contamination and Toxicology. ,vol. 54, pp. 349- 356 ,(1995) , 10.1007/BF00195104
A.K.D. Liem, A.P.J.M. de Jong, J.A. Marsman, A.C. den Boer, G.S. Groenemeijer, R.S. den Hartog, G.A.L. de Korte, R. Hoogerbrugge, P.R. Kootstra, H.A. van 't Klooster, A rapid clean-up procedure for the analysis of polychlorinated dibenzo-p-dioxins and dibenzofurans in milk samples Chemosphere. ,vol. 20, pp. 843- 850 ,(1990) , 10.1016/0045-6535(90)90191-U
P Fürst, C Fürst, K Wilmers, Human milk as a bioindicator for body burden of PCDDs, PCDFs, organochlorine pesticides, and PCBs. Environmental Health Perspectives. ,vol. 102, pp. 187- 193 ,(1994) , 10.1289/EHP.102-1566908
Abraham Brouwer, Ulf G. Ahlborg, F.X. Rolaf van Leeuwen, M. Mark Feeley, Ulf G. Ahlborg, Hans Beck, Bram Brouwer, Anders Carlsen, Mark Feeley, Hans Helge, Jens-Jørgen Larsen, John Christian Larsen, Elle Larsen, Dieter Neubert, F.X. Rolaf van Leeuwen, Maged Younes, Report of the WHO working group on the assessment of health risks for human infants from exposure to PCDDs, PCDFs and PCBs. Chemosphere. ,vol. 37, pp. 1627- 1643 ,(1998) , 10.1016/S0045-6535(98)00230-6
H Beck, A Dross, W Mathar, PCDD and PCDF exposure and levels in humans in Germany. Environmental Health Perspectives. ,vol. 102, pp. 173- 185 ,(1994) , 10.1289/EHP.94102S1173
M. Schuhmacher, J.L. Domingo, J.M. Llobet, H. Kiviranta, T. Vartiainen, PCDD/F concentrations in milk of nonoccupationally exposed women living in southern Catalonia, Spain Chemosphere. ,vol. 38, pp. 995- 1004 ,(1999) , 10.1016/S0045-6535(98)00359-2
A. Schecter, O. Päpke, A. Lis, M. Ball, J.J. Ryan, J.R. Olson, Lingjun Li, H. Kessler, Decrease in milk and blood dioxin levels over two years in a mother nursing twins: Estimates of decreased maternal and increased infant dioxin body burden from nursing Chemosphere. ,vol. 32, pp. 543- 549 ,(1996) , 10.1016/0045-6535(95)00248-0
M Van den Berg, L Birnbaum, A T Bosveld, B Brunström, P Cook, M Feeley, J P Giesy, A Hanberg, R Hasegawa, S W Kennedy, T Kubiak, J C Larsen, F X van Leeuwen, A K Liem, C Nolt, R E Peterson, L Poellinger, S Safe, D Schrenk, D Tillitt, M Tysklind, M Younes, F Waern, T Zacharewski, Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife Environmental Health Perspectives. ,vol. 106, pp. 775- 792 ,(1998) , 10.1289/EHP.98106775