Metabolic clearance rate and plasma half life of alpha-human atrial natriuretic peptide in man.
作者： T.G. Yandle , A.M. Richards , M.G. Nicholls , R. Cuneo , E.A. Espiner
DOI: 10.1016/0024-3205(86)90137-2
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摘要: The disappearance and metabolic clearance rate (MCR) of alpha human atrial natriuretic peptide (alpha h-ANP) has been studied in normal man by radioimmunoassay the plasma extracts. After an intravenous (iv) bolus injection 100 micrograms h-ANP, levels immunoreactive h-ANP (IR-alpha hANP) unextracted fell rapidly exponentially during first 10 min (t1/2 = 2.5 min), after which declined more slowly to reach basal values 30 injection. Venous extracts, purified Sep Pak cartridges, were used calculate MCR IR-alpha hANP under steady state conditions constant iv infusion (200 over 60 min) healthy volunteers. Calculated from venous samples was 2.4 L/min volume distribution 10.7 L. cessation infusions, (rapid phase) 3.1 min. These studies show that is metabolized at rates similar other vasoactive hormones such as angiotensin II vasopressin.
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sci-hub.se 参考文章(10)
Kenji Kangawa, Ayako Fukuda, Hisayuki Matsuo, Structural identification of β- and γ-human atrial natriuretic polypeptides Nature. ,vol. 313, pp. 397- 400 ,(1985) , 10.1038/313397A0
FC GREENWOOD, WM HUNTER, JS GLOVER, THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY Biochemical Journal. ,vol. 89, pp. 114- 123 ,(1963) , 10.1042/BJ0890114
Jannik Hilsted, Niels J. Christensen, Sten Madsbad, Whole Body Clearance of Norepinephrine. THE SIGNIFICANCE OF ARTERIAL SAMPLING AND OF SURGICAL STRESS Journal of Clinical Investigation. ,vol. 71, pp. 500- 505 ,(1983) , 10.1172/JCI110794
MICHAEL G. BESSER, DAVID N. ORTH, WENDELL E. NICHOLSON, RICHARD L. BYYNY, KAORU ABE, JEAN P. WOODHAM, Dissociation of the Disappearance of Bioactive and Radioimmunoreactive ACTH from Plasma in Man The Journal of Clinical Endocrinology and Metabolism. ,vol. 32, pp. 595- 603 ,(1971) , 10.1210/JCEM-32-5-595
A.M. Richards, H. Ikram, T.G. Yandle, M.G. Nicholls, M.W.I. Webster, E.A. Espiner, RENAL, HAEMODYNAMIC, AND HORMONAL EFFECTS OF HUMAN ALPHA ATRIAL NATRIURETIC PEPTIDE IN HEALTHY VOLUNTEERS The Lancet. ,vol. 325, pp. 545- 549 ,(1985) , 10.1016/S0140-6736(85)91207-3
T. Janáky, F. A. László, F. Sirokmán, J.-L. Morgat, Biological half-life and organ distribution of [3H]8-arginine-vasopressin in the rat. Journal of Endocrinology. ,vol. 93, pp. 295- 303 ,(1982) , 10.1677/JOE.0.0930295
KUNIAKI MATSUI, LEONARD SHARE, BIN C. WANG, JOAN T. CROFTON, DAVID P. BROOKS, Effects of Changes in Steady State Plasma Vasopressin Levels on Renal and Urinary Vasopressin Clearances in the Dog Endocrinology. ,vol. 112, pp. 2107- 2113 ,(1983) , 10.1210/ENDO-112-6-2107
R. L. HODGE, K. K. F. NG, J. R. VANE, Disappearance of angiotensin from the circulation of the dog. Nature. ,vol. 215, pp. 138- 141 ,(1967) , 10.1038/215138A0
J. Tang, R.J. Webber, D. Chang, J.K. Chang, J. Kiang, E.T. Wei, Depressor and natriuretic activities of several atrial peptides Regulatory Peptides. ,vol. 9, pp. 53- 59 ,(1984) , 10.1016/0167-0115(84)90007-7
AE Doyle, WJ Louis, G Jerums, EC Osborn, Metabolism and blood levels following infusion of a radioactive analog of angiotensin. American Journal of Physiology. ,vol. 215, pp. 164- 168 ,(1968) , 10.1152/AJPLEGACY.1968.215.1.164