Mitochondrial Homeostasis in Acute Organ Failure
作者： L. Jay Stallons , Jason A. Funk , Rick G. Schnellmann
DOI: 10.1007/S40139-013-0023-X
关键词:
摘要: The kidneys compose approximately 0.5% of the body mass but consume about 10% oxygen in cellular respiration. This discordance is due to high energy demands on kidney for reabsorption filtered blood components and makes sensitive mitochondrial stress, primary source ATP. Regardless etiology, acute injury (AKI) almost always involves aspects dysfunction. Recent evidence from experimental models suggests that preserving function or promoting repair rescues renal during AKI. In this review we discuss effect AKI disruption homeostasis, how dynamic processes biogenesis, fission/fusion, mitophagy influence recovery.
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