Detection of new fumonisin mycotoxins and fumonisin-like compounds by reversed-phase high-performance liquid chromatography/electrospray ionization ion trap mass spectrometry.
作者： Tibor Bartók , Árpád Szécsi , András Szekeres , Ákos Mesterházy , Mihály Bartók
DOI: 10.1002/RCM.2607
关键词:
摘要: Fumonisins were produced in a rice culture infected with Fusarium verticillioides. To decrease the possibility of formation artifacts, fumonisins analyzed by reversed-phase high-performance liquid chromatography electrospray ionization ion trap tandem mass spectrometry (RP-HPLC/ESI-IT-MS2) immediately after extraction material without any sample clean-up. In addition to already known fumonisins, numerous new fumonisin mycotoxins and fumonisin-like compounds detected. On basis IT-MS2 data, detailed fragmentation pathways including mechanisms proposed for different series fumonisins. The retention times, masses protonated molecules product ions backbones characteristic neutral losses from suggested their structures (applying well-known designation): iso-FA1a,b, iso-FB1a–d, iso-FB2,3a–e, PHFB2a–c, PHFB4a–d, FB5/iso-FB5a–d, FBK1 2TCA, FBK4 FC2, iso-FC2,3, PHFC4, FD FBX series. relative quantities found extract expressed as percentages FB1 (0.02–100%). backbone compound denoted contained fewer carbon atoms than C19 or C20 may well be precursor longer compounds. For (12 compounds), one two OH groups attached esterified carboxylic acids other tricarballylic acid, such cis-aconitic oxalylsuccinic acid oxalylfumaric acid. Copyright © 2006 John Wiley & Sons, Ltd.
core.ac.uk
harvard.edu
sci-hub.se 参考文章(53)
Maria E. Cawood, Wentzel C. A. Gelderblom, Robert Vleggaar, Yosef Behrend, Pieter G. Thiel, Walter F. O. Marasas, Isolation of the fumonisin mycotoxins: A quantitative approach Journal of Agricultural and Food Chemistry. ,vol. 39, pp. 1958- 1962 ,(1991) , 10.1021/JF00011A014
J.M. Soriano, S. Dragacci, Intake, decontamination and legislation of fumonisins in foods Food Research International. ,vol. 37, pp. 367- 374 ,(2004) , 10.1016/J.FOODRES.2004.01.008
S. Marin, V. Sanchis, I. Vinas, R. Canela, N. Magan, Effect of water activity and temperature on growth and fumonisin B1 and B2 production by Fusarium proliferatum and F. moniliforme on maize grain Letters in Applied Microbiology. ,vol. 21, pp. 298- 301 ,(1995) , 10.1111/J.1472-765X.1995.TB01064.X
Michael J Sweeney, Alan DW Dobson, Mycotoxin production by Aspergillus, Fusarium and Penicillium species International Journal of Food Microbiology. ,vol. 43, pp. 141- 158 ,(1998) , 10.1016/S0168-1605(98)00112-3
Ravi S. Bojja, Ronald L. Cerny, Robert H. Proctor, Liangcheng Du, Determining the Biosynthetic Sequence in the Early Steps of the Fumonisin Pathway by Use of Three Gene-Disruption Mutants of Fusarium verticillioides Journal of Agricultural and Food Chemistry. ,vol. 52, pp. 2855- 2860 ,(2004) , 10.1021/JF035429Z
W Seefelder, G Schwerdt, R Freudinger, M Gekle, H.-U Humpf, Liquid chromatography/electrospray ionisation-mass spectrometry method for the quantification of sphingosine and sphinganine in cell cultures exposed to fumonisins. Journal of Chromatography B. ,vol. 780, pp. 137- 144 ,(2002) , 10.1016/S1570-0232(02)00440-3
György Szöllősi, Imre Bucsi, Szabolcs Cserényi, Mihály Bartók, Study of fragmentation pattern and adsorption of 9-O-(triphenylsilyl)-10,11-dihydrocinchonidine on platinum by hydrogen/deuterium exchange using electrospray ionization ion-trap tandem mass spectrometry. Rapid Communications in Mass Spectrometry. ,vol. 19, pp. 3743- 3748 ,(2005) , 10.1002/RCM.2252
W.Thomas Shier, Hamed K. Abbas, Farid A. Badria, Complete structures of the sphingosine analog mycotoxins fumonisin B1 and AAL toxin TA: Absolute configuration of the side chains Tetrahedron Letters. ,vol. 36, pp. 1571- 1574 ,(1995) , 10.1016/0040-4039(95)00090-Y
Steven M. Musser, Martha L. Gay, Eugene P. Mazzola, Ronald D. Plattner, Identification of a new series of fumonisins containing 3-hydroxypyridine. Journal of Natural Products. ,vol. 59, pp. 970- 972 ,(1996) , 10.1021/NP960349T
Sonia Marin, Vicente Sanchis, Naresh Magan, None, Water activity, temperature, and pH effects on growth of Fusarium moniliforme and Fusarium proliferatum isolates from maize Canadian Journal of Microbiology. ,vol. 41, pp. 1063- 1070 ,(1995) , 10.1139/M95-149