Survival of the Fittest: How Bacterial Pathogens Utilize Bile To Enhance Infection

摘要: Bacterial pathogens have coevolved with humans in order to efficiently infect, replicate within, and be transmitted new hosts ensure survival a continual infection cycle. For enteric pathogens, the ability adapt numerous host factors under harsh conditions of gastrointestinal tract is critical for establishing infection. One such factor readily encountered by bacteria bile, an innately antimicrobial detergent-like compound essential digestion nutrient absorption. Not only evolved resist bactericidal but these also utilize bile as signal enhance virulence regulation efficient This review provides comprehensive up-to-date analysis bile-related research pathogens. From common responses unique expression specific factors, each pathogen has overcome significant challenges establish tract. Utilization modulate led important insights our understanding mechanisms many Further on exposed this vivo will benefit therapeutic vaccine development ultimately success at combating elite