Vitamin D supplementation and body weight status: a systematic review and meta-analysis of randomized controlled trials

摘要: Vitamin D is anticipated to have many extra-skeletal health benefits. We questioned whether supplementation with the vitamin influenced body weight and composition. A systematic review meta-analysis was conducted on high-quality, randomized controlled trials (RCTs) that had supplemented without imposing any caloric restriction. Eighteen reporting either weight, mass index (BMI), fat (FM), percentage (%FM) or lean (LBM) met our criteria. Twelve studies provided required data for meta-analysis. did not influence standardized mean difference (SMD) FM, %FM LBM. small but non-significant decrease in BMI (SMD = -0.097, 95% confidence interval: [-0.210, 0.016], P 0.092) observed. Meta-regression confirmed neither absolute status achieved nor its change from baseline SMD of obesity measure. However, increasing age subjects predicted a shift FM towards placebo treatment, whereas greater women these favoured following D. measures adiposity absence potential confounding by gender encountered.