Syndrome coronaire aigu : y a-t-il une place pour les anticoagulants oraux directs ?
作者： Guillaume Cayla , Florence Leclercq , Laurent Schmutz , Luc Cornillet , Bertrand Ledermann
DOI: 10.1016/J.LPM.2016.07.022
关键词:
摘要: Venous thromboembolism and atrial fibrillation are two important indications of direct oral anticoagulants. Acute coronary syndrome is another potential indication prolonged antithrombotic therapy in addition to antiplatelet therapy. Phase 2 and 3 studies were conducted with different molecules at doses acute dual Studies have not shown a reduction ischemic events for dabigatran apixaban, but an excess bleeding complications was observed. A stent thrombosis observed low dose rivaroxaban taken twice day increased risk major complications. This data used obtain European marketing authorization the positioning molecule remains difficult. new study currently being test association P2Y12 inhibitor without aspirin. Direct anticoagulants can also be after percutaneous intervention patients requiring long-term Dedicated studies confirm optimal ideal drugs.
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