PEG–PLGA copolymers bearing carboxylated side chains: Novel hydrogels with enhanced crosslinking via ionic interactions
作者： Sytze J. Buwalda , Abderrahmane Amgoune , Didier Bourissou
DOI: 10.1002/POLA.27962
关键词:
摘要: Novel water-soluble amphiphilic block copolymers with pendant carboxylic acid groups are synthesized and used for the preparation of ionically crosslinked hydrogels. d,l-Lactide (DLLA) l−3-(2-benzyloxycarbonyl)ethyl-1,4-dioxane-2,5-dione (BED) copolymerized at different ratios via organo-catalyzed ring-opening polymerization using a hydroxyl-terminated poly(ethylene glycol) (PEG–OH) macroinitiator. Dynamic light-scattering experiments show that, low concentrations, aqueous solutions these PEG-P(BED-DLLA) form micelles aggregates. At higher thermo-sensitive gels obtained, exhibiting reversible gel-to-sol transition upon temperature increase. Ionic interactions between COOH metal ions (Cu2+ or Ca2+) shown to significantly shift gel–sol temperatures. Thus, introduction enhances water solubility PEG–polyester copolymer allows additional crosslinking functionalized hydrogels improved physical properties, making this new class interesting various applications. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Chem. 2016, 54, 1222–1227
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