Sarcopenia and mortality risk in frail older persons aged 80 years and older: results from ilSIRENTE study

摘要: Background and aims: sarcopenia has been indicated as a reliable marker of frailty poor prognosis among the oldest individuals. We evaluated impact on risk all-cause death in population frail older persons living community. Methods: we analysed data from Aging Longevity Study, prospective cohort study that collected all subjects aged 80 years residing Sirente geographic area (n= 364). The present analysis was conducted those who were between 85 age at time baseline assessment 197). main outcome measure mortality over 7-year follow-up. According to European Working Group Sarcopenia Older People (EWGSOP) criteria, diagnosis required documentation low muscle mass either strength or physical performance. Cox proportional regression models used estimate crude adjusted hazard ratios 95% confidence intervals by presence sarcopenia. Results: using EWGSOP-suggested 43 with (21.8%) identified. During follow-up, 29 (67.4%) participants died compared 63 (41.2%) without (P< 0.001). After adjusting for potential confounders including age, gender, education, activities daily (ADL) impairment, body index, hypertension, congestive heart failure, chronic obstructive pulmonary disease, number diseases, TNF-α, had higher causes non-sarcopenic (HR: 2.32, CI: 1.01–5.43). Conclusions: our results obtained representative sample very old show is associated mortality, independently other clinical functional variables.