Developmental alterations of frontal-striatal-thalamic connectivity in obsessive-compulsive disorder.

摘要: Objective Pediatric obsessive-compulsive disorder is characterized by abnormalities of frontal–striatal–thalamic circuitry that appear near illness onset and persist over its course. Distinct frontal-striatal-thalamic loops through cortical centers for cognitive control (anterior cingulate cortex) emotion processing (ventral medial frontal follow unique maturational trajectories, altered connectivity within distinct may be differentially associated with OCD at specific stages development. Method Altered development striatal thalamic to cortex was tested in 60 patients compared 61 healthy subjects child, adolescent, adult development, using resting-state functional MRI. Results the youngest reduced dorsal striatum thalamus rostral anterior cortex, respectively. Increased ventral observed all developmental stages. In child patients, between correlated severity. Conclusions Frontal–striatal–thalamic involved are hypoconnected young onset, whereas implicated hyperconnected throughout illness.