作者: Kentaro Hirao , Gregory M. Pontone , Gwenn S. Smith
DOI: 10.1016/J.NEUBIOREV.2014.11.010
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摘要: Abstract Neuropsychiatric symptoms (NPS) are very common in neurodegenerative diseases and a major contributor to disability caregiver burden. There is accumulating evidence that NPS may be prodrome and/or “risk factor” of diseases. The medications used treat these younger patients not effective with disease have serious side effects. An understanding the neurobiology critical for development more intervention strategies. Targeting also implications prevention cognitive or motor decline. Molecular brain imaging represents bridge between basic clinical observations provides many opportunities translation from animal models human post-mortem studies vivo studies. Alzheimer's (AD) Parkinson's (PD) reviewed primary focus on positron emission tomography NPS. Future directions field molecular AD PD understand will discussed.