Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the β2-adrenergic receptor in neurons.

作者: Hai Qian , Tommaso Patriarchi , Jennifer L Price , Lucas Matt , Boram Lee

DOI: 10.1126/SCISIGNAL.AAF9659

关键词:

摘要: The L-type Ca2+ channel Cav1.2 controls heart rate and neuronal excitability. Qian et al . found that enhancement of activity in the brain by β-adrenergic receptor (βAR) signaling required phosphorylation Ser1928, whereas heart, this site was dispensable for βAR-mediated regulation. In contrast to those from wild-type mice, hippocampal neurons which Ser1928 mutated alanine, did not exhibit increased calcium response stimulation. Phosphorylation involved through β2AR, but β1AR, event enabled a particular form long-term potentiation, process linked learning memory. These results were marked regulation cardiomyocytes, β1AR independent Ser1928. This differential implies tissue-specific therapeutics could be identified.

参考文章(102)
J.W. Hell, C.T. Yokoyama, L.J. Breeze, C. Chavkin, W.A. Catterall, Phosphorylation of presynaptic and postsynaptic calcium channels by cAMP-dependent protein kinase in hippocampal neurons. The EMBO Journal. ,vol. 14, pp. 3036- 3044 ,(1995) , 10.1002/J.1460-2075.1995.TB07306.X
J.W. Hell, C.T. Yokoyama, S.T. Wong, C Warner, T.P. Snutch, W.A. Catterall, Differential phosphorylation of two size forms of the neuronal class C L-type calcium channel alpha 1 subunit. Journal of Biological Chemistry. ,vol. 268, pp. 19451- 19457 ,(1993) , 10.1016/S0021-9258(19)36536-6
Hey-Kyoung Lee, Michaela Barbarosie, Kimihiko Kameyama, Mark F. Bear, Richard L. Huganir, Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity. Nature. ,vol. 405, pp. 955- 959 ,(2000) , 10.1038/35016089
Amy R Halt, Robert F Dallapiazza, Yu Zhou, Ivar S Stein, Hai Qian, Scott Juntti, Sonja Wojcik, Nils Brose, Alcino J Silva, Johannes W Hell, CaMKII binding to GluN2B is critical during memory consolidation The EMBO Journal. ,vol. 31, pp. 1203- 1216 ,(2012) , 10.1038/EMBOJ.2011.482
Livia C. Hool, Robert D. Harvey, Role of β1- and β2-adrenergic receptors in regulation of Cl− and Ca2+ channels in guinea pig ventricular myocytes American Journal of Physiology-heart and Circulatory Physiology. ,vol. 273, ,(1997) , 10.1152/AJPHEART.1997.273.4.H1669
Yuan Lu, Mingxu Zhang, Indra A. Lim, Duane D. Hall, Margaret Allen, Yuliya Medvedeva, G. Stanley McKnight, Yuriy M. Usachev, Johannes W. Hell, AKAP150-anchored PKA activity is important for LTD during its induction phase. The Journal of Physiology. ,vol. 586, pp. 4155- 4164 ,(2008) , 10.1113/JPHYSIOL.2008.151662
Gerald W. Zamponi, Joerg Striessnig, Alexandra Koschak, Annette C. Dolphin, The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential Pharmacological Reviews. ,vol. 67, pp. 821- 870 ,(2015) , 10.1124/PR.114.009654
Marcie Colledge, Rebecca A Dean, Gregory K Scott, Lorene K Langeberg, Richard L Huganir, John D Scott, Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex. Neuron. ,vol. 27, pp. 107- 119 ,(2000) , 10.1016/S0896-6273(00)00013-1
Duane D. Hall, Monika A. Davare, Mei Shi, Margaret L. Allen, Michael Weisenhaus, G. Stanley McKnight, Johannes W. Hell, Critical Role of cAMP-dependent Protein Kinase Anchoring to the L-type Calcium Channel Cav1.2 via A-kinase Anchor Protein 150 in Neurons Biochemistry. ,vol. 46, pp. 1635- 1646 ,(2007) , 10.1021/BI062217X
Gregory C. Amberg, Manuel F. Navedo, Local Regulation of L-Type Ca2+ Channel Sparklets in Arterial Smooth Muscle Microcirculation. ,vol. 20, pp. 290- 298 ,(2013) , 10.1111/MICC.12021