作者: Hai Qian , Tommaso Patriarchi , Jennifer L Price , Lucas Matt , Boram Lee
DOI: 10.1126/SCISIGNAL.AAF9659
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摘要: The L-type Ca2+ channel Cav1.2 controls heart rate and neuronal excitability. Qian et al . found that enhancement of activity in the brain by β-adrenergic receptor (βAR) signaling required phosphorylation Ser1928, whereas heart, this site was dispensable for βAR-mediated regulation. In contrast to those from wild-type mice, hippocampal neurons which Ser1928 mutated alanine, did not exhibit increased calcium response stimulation. Phosphorylation involved through β2AR, but β1AR, event enabled a particular form long-term potentiation, process linked learning memory. These results were marked regulation cardiomyocytes, β1AR independent Ser1928. This differential implies tissue-specific therapeutics could be identified.