Effects of atorvastatin on the clearance of triglyceride-rich lipoproteins in familial combined hyperlipidemia.
作者： M. Castro Cabezas , C. Verseyden , S. Meijssen , H. Jansen , D. W. Erkelens
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摘要: Familial combined hyperlipidemia (FCHL) patients have an impaired catabolism of postprandial triglyceride (TG)-rich lipoproteins (TRLs). We investigated whether atorvastatin corrects the delayed clearance large TRLs in FCHL by evaluating acute Intralipid (10%) and after oral fat-loading tests. Sixteen matched controls were included. Atorvastatin reduced fasting plasma TG (from 3.6 ± 0.4 to 2.5 0.3 mm; mean sem) without major effects on apolipoprotein B48 (apoB48) apoB100 TRLs. significantly intermediate density lipoprotein (Svedberg flotation, 12–20)-apoB100 concentrations. After Intralipid, TRL showed similar kinetics before treatment, although compared with controls, was only slower untreated FCHL, suggesting improvement atorvastatin. Investigated tests, very low (Sf20–6...
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