SARS-CoV-2 infections and antibody responses among health care workers in a Spanish hospital after a month of follow-up

摘要: Abstract Background At the peak of COVID-19 pandemic in Spain, cumulative prevalence SARS-CoV-2 infection a cohort 578 randomly selected health care workers (HCW) from Hospital Clinic de Barcelona was 11.2%. Methods A follow-up survey one month after baseline (April-May 2020) measured by real time reverse-transcriptase polymerase chain reaction (rRT-PCR) and IgM, IgA, IgG subclasses to receptor-binding domain spike protein Luminex. Prevalence defined positive rRT-PCR and/or antibody seropositivity. Results The at 1 14.9% (84/565) seroprevalence 14.5% (82/565) for IgM IgA. We found 25 (5%) new infections participants without previous evidence (501) two seroreverted Among seropositive baseline, IgA levels generally declined (antibody decay rates 0.49 (95% CI, 0.40-0.60) 0.34 0.26-0.44)), respectively. Eight percent 11% Subjects reporting COVID-19-like symptoms laboratory other technicians had higher risk infection. most frequent subclass responses were IgG1 IgG2, followed IgG3, with IgG1, only IgA1 but no IgA2 detected. Conclusions Our findings highlight importance continuous improved surveillance HCW, particularly high groups. have implications studies using these isotypes.