MRI of central nervous system abnormalities in childhood leukemia.

作者: Mehmet Coşkun , Esra Meltem Kayahan Ulu , Hüseyin Gürkan Töre , Ahmet Bayrak , Durmuş Güngör

DOI:

关键词:

摘要: Purpose To document the imaging abnormalities seen in central nervous system (CNS) childhood leukemia or as complications of its treatment. Materials and methods Magnetic resonance (MRI) 15 children with neurologic treatment were reviewed retrospectively. The first group consisted patients CNS detected prior to during treatment, within three months after completion Patients by MRI following included second group. Results Among children, six had two more different abnormalities. 12 orbital, temporal, cerebellopontine angle, spinal chloroma; bilateral subdural hematoma subacute stage; multifocal intraparenchymal hemorrhage; retinal hemorrhage detachment; pons mesencephalon; PRES (posterior reversible leukoencephalopathy syndrome); leukemic infiltration 3(rd), left 7(th), 8(th) cranial nerves; meningeal leukemia. Three including radiation necrosis secondary brain tumor, osteomyelitis L3 vertebra, Conclusion wide spectrum that occur for is related method. Because many are treatable, early diagnosis essential.

参考文章(20)
Russell W. Walker, Neurologic complications of leukemia. Neurologic Clinics. ,vol. 9, pp. 989- 999 ,(1991) , 10.1016/S0733-8619(18)30261-5
Naomi Winick, Robert Bash, Nancy Rollins, Timothy Booth, Acute Methotrexate Neurotoxicity: Findings on Diffusion-Weighted Imaging and Correlation with Clinical Outcome American Journal of Neuroradiology. ,vol. 25, pp. 1688- 1695 ,(2004)
Ronald L. Sham, Pradyumna D. Phatak, Peter A. Kouides, Jo Ann S. Janas, Victor J. Marder, Hematologic neoplasia and the central nervous system. American Journal of Hematology. ,vol. 62, pp. 234- 238 ,(1999) , 10.1002/(SICI)1096-8652(199912)62:4<234::AID-AJH6>3.0.CO;2-B
Hermann Brenner, Peter Kaatsch, Tatjana Burkhardt-Hammer, D�rthe O. Harms, Martin Schrappe, J�rg Michaelis, Long-term survival of children with leukemia achieved by the end of the second millennium Cancer. ,vol. 92, pp. 1977- 1983 ,(2001) , 10.1002/1097-0142(20011001)92:7<1977::AID-CNCR1717>3.0.CO;2-W
Enrico Balleari, Serena Panarello, Elisabetta Capello, Marco Grosso, Caterina Passalia, Paola Pitto, Francesca Raggi, Luca Roccatagliata, Francesco Cabiddu, Riccardo Ghio, Granulocytic sarcoma: an unusual cause of spinal cord compression International Journal of Clinical Oncology. ,vol. 12, pp. 234- 237 ,(2007) , 10.1007/S10147-006-0645-7
M H Pui, B D Fletcher, J W Langston, Granulocytic sarcoma in childhood leukemia: imaging features. Radiology. ,vol. 190, pp. 698- 702 ,(1994) , 10.1148/RADIOLOGY.190.3.8115614
C. Binder, M. Tiemann, D. Haase, A. Humpe, M. Kneba, Isolated meningeal chloroma (granulocytic sarcoma)--a case report and review of the literature. Annals of Hematology. ,vol. 79, pp. 459- 462 ,(2000) , 10.1007/S002770000165
L E Ginsberg, N E Leeds, Neuroradiology of leukemia. American Journal of Roentgenology. ,vol. 165, pp. 525- 534 ,(1995) , 10.2214/AJR.165.3.7645463
R. Menon, D. Muzumdar, A. Shah, A. Goel, Glioblastoma Multiforme following Cranial Irradiation and Chemotherapy for Acute Lymphocytic Leukaemia Pediatric Neurosurgery. ,vol. 43, pp. 369- 374 ,(2007) , 10.1159/000106385
JosephA. Sparano, Rasim Gucalp, JosefinaF. Llena, FranklinG. Moser, PeterH. Wiernik, Cerebral infection complicating systemic aspergillosis in acute leukemia: clinical and radiographic presentation. Journal of Neuro-oncology. ,vol. 13, pp. 91- 100 ,(1992) , 10.1007/BF00172950