Imaging of cortical spreading depression by EIT: implications for localization of epileptic foci

摘要: Severe epileptics may require curative neurosurgery. Sometimes focus localization requires recording with electrodes inserted deep into the brain, which cause death or permanent neurological damage. Since epileptic seizures are associated marked changes in cerebral impedance, we propose that EIT sub-dural (inserted between brain and skull) could provide a superior less dangerous method for of foci. The purpose these experiments was to determine whether be used localize origin seizure activity. In terms impedance characteristics, an appropriate model is cortical spreading depression animal brain. Six rabbits were anaesthetized paralysed exposed. images DC potentials recorded from array 16 on during induced by stimulus. Cortical localized accuracy 8.7% +/- 6.4% (mean SD) electrode diameter. errors appeared distributed randomly. phantom similar geometry, error 5% after correction systematic component. Results sufficiently encouraging intend extend this study human patients.