Digigait quantitation of gait dynamics in rat rheumatoid arthritis model.

摘要: Introduction. Rheumatoid arthritis (RA) is characterized by joint pain, allodynia and hyperalgesia. The rat carrageenan model utilizes inflammation-associated pain following injection of the knee to RA. Traditional assessment in these models behavioral scoring or manual measurements, methods that are labor intensive prone subjective interpretation. This study Digigait™ system objectively quantify movement gait dynamics a monoarthrit- ic model. Material Methods. A pilot rats selected "natural" runners using Digigait™, also measured inter intraday variability as well effects anesthesia on dynamics. In main study, 12 female were tested at base- line, divided two groups 6 rats, briefly anesthetized with isoflurane injected 60 Il 2% lambda vehicle; Digigait testing was repeated 2 4 hours post data analyzed. Results. Selection significantly contributed accuracy reproducibility parameters obtained system. There min- imal intra day variation between individual minutes had no effect dynam- administration. highly reproducible signature limb, coordinated adaptation during locomotion non-affected limbs noted short-term changes car- rageenan injection. Conclusion. found be an objective reliable method for quantification early consistent hyperalgesia inflammatory