A study of bipolar disorder using magnetization transfer imaging and voxel-based morphometry.

摘要: Bipolar disorder (BP) traditionally has been considered as a recurrent illness with full recovery between episodes, and the absence of neuropathological abnormalities usually taken for granted. In recent times, realization that, many BP carries poor prognosis, that cognitive deficits are often persistent structural brain detectable modern imaging techniques spurred search its substrate. The shortcomings post-mortem studies make use sensitive to changes compelling. We report here first study patients using two such in conjunction: magnetization transfer (MTI) voxel-based morphometry (VBM). Thirty-nine (13 males 26 females; 28 BPI 11 BPII) 35 healthy controls were investigated. Both high-resolution volumetric T1-weighted images MT acquired from all subjects. Images processed voxel-by-voxel analysis statistical parametric mapping 2 (SPM2). ratio MTR, an index indicative loss macromolecular density, was reduced right subgenual anterior cingulate adjacent white matter bipolar compared controls. VBM did not reveal significant differences grey matter, but density significantly bilaterally prefrontal areas encompassing fronto-striatal connections. Our findings suggest subtle present subgyral changes. These keeping those previously reported illustrate important similarities (involvement cingulate) (lack widespread cortical BP) our previous schizophrenic same methodology.