作者: F Nensa , W Marek , E Marek , HJ Smith , M Kohlhäufl
DOI: 10.1186/2047-783X-14-S4-170
关键词:
摘要: Bronchial challenge tests by inhalation of aerosolized methacholine (MCH) are commonly used in the clinical diagnosis airway hyperresponsiveness (AHR). While detection narrowing relies on patient's cooperation performing forced spirometry, body plethysmographic measurements resistance less depending and do not alter respiratory tract maximal maneuvers. Hence we compared both methods concerning their value correlation during MCH challenges patients with asthma. Cumulative test, consisting up to 5 steps, evaluated plethysmography each step were performed 155 bronchial Airway responses recorded at application (Master-Screen Body, Cardinal Health, Hochberg). At baseline test after crossing provocation dose (PD) threshold (PD+100 sReff), expirations FEV1, FVC, FEV1 %FVC measured. Using regression analysis parameters taking as covariate, could extrapolate missing spirometric values interpolate estimated when PD (PD-20 FEV1) between two consecutive measurements. The administered PD+100 doses for specific resistance, sRtot, sReff Rtot Reff, PD-20 %FVC. Regarding found a mild, moderate, or severe AHR 114 (75%), but only 50 (32%) according FEV1. A statistical showed strongly linear correlated no significant results spirometry challenges, be most sensitive parameter detect AHR. Raw is largely independent height gender facilitating interpretation carried out longitudinally.