Smaller Global and Regional Cortical Volume in Combat-Related Posttraumatic Stress Disorder

摘要: CONTEXT: Two sets of findings predict smaller cerebral cortical gray matter volume in adult posttraumatic stress disorder (PTSD). Measures intracranial tissue and have been observed to be adolescents with maltreatment-related PTSD. Second, lower intelligence, a risk factor for PTSD, is associated volumes. Nevertheless, our knowledge, only 1 study has globally adults OBJECTIVES: To apply recently developed method providing improved estimates estimate associations between PTSD selected regional volumes not yet investigated. DESIGN: Between-group comparison global patients combat-related controls. SETTING: Department Veterans Affairs medical centers large inpatient outpatient catchments. PARTICIPANTS: Ninety-seven combat-exposed veterans the Vietnam Persian Gulf wars. MAIN OUTCOME MEASURE: Global determined using FreeSurfer software program Desikan et al parcellation (modified). RESULTS: Cerebral volume, thickness, area were association Robust parahippocampal gyrus, superior temporal cortex, lateral orbital frontal pars orbitalis inferior gyrus. CONCLUSIONS: may chronic severe PTSD; however, extracted structural variables did mediate relations intelligence The 4 regions exhibiting especially this sample share involvement mechanisms subserving "top-down" facilitation identification objects words. Compromise these result difficulty relearning pretrauma schemata interpreting civilian physical social environments. Language: en