Age-Related Defects in Erythrocyte 2,3-Diphosphoglycerate Metabolism in Dementia
作者： Yury G Kaminsky , V Prakash Reddy , Ghulam Md Ashraf , Ausaf Ahmad , Valery V Benberin
关键词:
摘要: Alzheimer disease (AD) is the most common dementing illness. Metabolic defects in brain with aging contribute to pathogenesis of AD. These changes can be found systematically and thus used as potential biomarkers. Erythrocytes (RBCs) are passive "reporter cells" that not well studied In present study, we analyzed an array glycolytic related enzymes intermediates RBCs from patients AD non-Alzheimer dementia (NA), age-matched controls (AC) young adult (YC). characterized by higher activities hexokinase, phosphofructokinase, bisphosphoglycerate mutase phosphatase RBCs. our observed displayed significantly lower AC. However, similar or were NA groups compared YC group. 2,3-diphosphoglycerate (2,3-DPG) levels decreased patients. The pattern between above indices strongly correlates each other. Collectively, data suggested associated chronic disturbance 2,3-DPG metabolism may play a pivotal role physiological processes, which predispose elderly subjects NA.
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mst.edu参考文章(48)
Nazem Bassil, Chirine Mollaei, Alzheimer's dementia: a brief review. Le Journal médical libanais. The Lebanese medical journal. ,vol. 60, pp. 192- ,(2012)
Jens G. Nørby, Coupled assay of Na+,K+-ATPase activity. Methods in Enzymology. ,vol. 156, pp. 116- 119 ,(1988) , 10.1016/0076-6879(88)56014-7
Gary E Gibson, Oxidative processes in the brain and non-neuronal tissues as biomarkers of Alzheimer s disease Frontiers in Bioscience. ,vol. 7, pp. d1007- 1015 ,(2002) , 10.2741/A827
G. G. Fillenbaum, A. Heyman, Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neurology. ,vol. 44, pp. 228- 228 ,(2002) , 10.1002/0470846410.CH42(III)
J M Rifkind, O O Abugo, OXIDATION OF HEMOGLOBIN AND THE ENHANCEMENT PRODUCED BY NITROBLUE TETRAZOLIUM Journal of Biological Chemistry. ,vol. 269, pp. 24845- 24853 ,(1994) , 10.1016/S0021-9258(17)31468-0
Chengxuan Qiu, Miia Kivipelto, Eva Von Strauss, Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention Dialogues in clinical neuroscience. ,vol. 11, pp. 111- 128 ,(2009) , 10.31887/DCNS.2009.11.2/CQIU
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Gjumrakch Aliev, Eldar Gasimov, Mark E Obrenovich, Kathryn Fischbach, Justin C Shenk, Mark A Smith, George Perry, Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels: Implication in the pathogenesis of Alzheimer’s disease Vascular Health and Risk Management. ,vol. 4, pp. 721- 730 ,(2008) , 10.2147/VHRM.S2608
Margarita L. Alexandrova, Petyo G. Bochev, Reduced extracellular phagocyte oxidative activity, antioxidant level changes and increased oxidative damage in healthy human blood as a function of age AGE. ,vol. 31, pp. 99- 107 ,(2009) , 10.1007/S11357-008-9085-9
E. A. Kosenko, I. N. Solomadin, N. V. Marov, N. I. Venediktova, A. S. Poghosyan, Yu. G. Kaminsky, Role of glycolysis and antioxidant enzymes in the toxicity of amyloid beta peptide Aβ25-35 to erythrocytes Russian Journal of Bioorganic Chemistry. ,vol. 34, pp. 586- 592 ,(2008) , 10.1134/S1068162008050087