Preferential Induction of c-fos versus c-jun Protooncogene during the Immediate Early Response of Pig Skin to γ-Rays

摘要: Abstract The involvement of the nuclear protooncogenes c- fos and jun in immediate early response pig dermis cells was studied after vivo γ-irradiation. Following high radiation doses (8 to 48 Gy), two were concomitantly induced, although induction preferential. Both inductions time dose dependent. Therefore, skin might involve heterodimeric activator protein 1 composed c-Fos c-Jun proteins. low (0.5 2 not induced. By contrast, dramatic observed 0.5 Gy, suggesting a specific role for at doses.