Continuous on-line monitoring of extracellular ascorbate depletion in the rat striatum induced by global ischemia with carbon nanotube-modified glassy carbon electrode integrated into a thin-layer radial flow cell.

摘要: This study describes a novel analytical system integrating in vivo microdialysis sampling with radial thin-layer flow cell single-walled carbon nanotube (SWNT)-modified glassy electrode as working for continuous and on-line monitoring of ascorbate depletion the rat striatum induced by global ischemia. The SWNTs, especially those after vacuum heat treatment at 500 °C, are found to be able enhance electron-transfer kinetics oxidation low potential (ca. −50 mV) possess strong ability against fouling. These properties essentially make it possible determine good stability high selectivity catecholamines their metabolites other electroactive species physiological levels. While being integrated assemble an system, is proved useful sensitive basal dialysate level its rat...