The Effect of Circumferential Tumor Location in Clinical Outcomes of Rectal Cancer Patients Treated With Total Mesorectal Excision

摘要: A positive circumferential resection margin is associated with a high risk of local recurrence and distant metastasis after total mesorectal excision for rectal cancer. The mesorectum thinner anteriorly than posteriorly, the may be higher anterior posterior tumors. We sought to determine effect tumor's position in circumference rectum on treatment outcomes cancer patients treated by excision. retrospectively analyzed 401 staged preoperative endorectal ultrasound sharp or without neoadjuvant therapy. Tumors were classified into four groups (anterior, posterior, lateral, circumferential) according location deepest point penetration ultrasound. Differences survival rates logistic regression analysis. Of tumors, 27 percent anterior, 26 32 15 circumferential. did not differ age, gender, tumor distance from anal verge, grade. pathology stages more advanced group, proportion uT4 tumors was group. Circumferential likely receive adjuvant radiation. After an average follow-up 44 months, 20 had developed (13 distant, 6 local, 1 local). Recurrence stage, proximity no Early stage chemoradiation lower improved survival. When controlled for, poor undifferentiated male shown have death. estimated five-year disease-free entire group 73 percent. Tumor main criterion estimate prognosis patients. within provide valuable clinical information. Anterior tend and, at least patients, has death other locations.