Human Milk and Matched Serum Demonstrate Concentration of Select miRNAs
作者： Wenyi Qin , Santanu Dasgupta , John Corradi , Edward R. Sauter
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摘要: Abstract Background: Pregnancy-associated breast cancers (PABCs), especially those diagnosed after childbirth, are often aggressive, with a poor prognosis. Factors influencing PABC largely unknown. Micro(mi)RNAs present in many human body fluids and shown to influence cancer development and/or growth. Subjects Methods: In six nursing mothers, we determined if cancer-associated miRNAs were (1) detectable milk (2) detectable, their relative expression fractions compared matched serum. We evaluated by quantitative PCR the of 11 (10a-5p, 16, 21, 100, 140, 145, 155, 181, 199, 205, 212) cells, fat supernatant (skim milk), Results: miRNA was all samples. For 10/11 miRNAs, mean control (ΔCt) values lowest exception being miR205. Relative concentration highest skim fraction for miRNAs. Ex...
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