Facilitation of kindling epileptogenesis by chronic stress may be mediated by intestinal microbiome

摘要: There has been growing interest in the role of intestinal microbiome brain disorders. We examined whether dysbiosis can predispose to epilepsy. The study was performed female and male Sprague-Dawley rats. To induce dysbiosis, rats were subjected chronic restraint stress (two 2-h long sessions per day, over 2 weeks). Cecal content from stressed sham-stressed donors transplanted via oral gavage recipients, which commensal microbiota had depleted by antibiotics. included following groups: (1) Sham stress, no transplant; (2) Stress, (3) Sham-stressed recipients with donors; (4) Stressed (5) (6) donors. After transplant, all animals kindling basolateral amygdala. Both subjects accelerated progression prolonged duration kindled seizures. Microbiome chronically rats, counteracted proepileptic effects stress. These findings directly implicate perturbations gut microbiome, particularly those associated increased susceptibility