Interplay between spinal cord and cerebral cortex metabolism in amyotrophic lateral sclerosis.
作者： Cecilia Marini , Silvia Morbelli , Angelina Cistaro , Cristina Campi , Claudia Caponnetto
DOI: 10.1093/BRAIN/AWY152
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摘要: We recently reported the potential of Hough transform in delineating spinal cord metabolism by 18F-fluorodeoxyglucose PET/CT scanning amyotrophic lateral sclerosis. The present study aimed to verify relationship between and brain 44 prospectively recruited patients affected sclerosis submitted whole-body PET/CT. Patients were studied highlight presence hypo- or hypermetabolism with respect healthy controls, multiple regression analysis was performed evaluate correlation metabolism. Our results confirmed higher uptake both cervical dorsal controls. This finding paralleled opposite pattern cortex that showed a generalized reduction tracer uptake. hypometabolism particularly evident wide regions frontal-dorsolateral while it did not involve midbrain. Bulbar disease onset associated similar degree metabolic activation cord. However, among patients, upper limb presentation more pronounced segment. Obtained data suggest differential neuro-pathological state temporal sequence progression.
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